BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression
oleh: Yilei Zhang, Li Zhuang, Boyi Gan
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2019-01-01 |
Deskripsi
The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive. Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression.