Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase
oleh: Ning Cui, Jun-Tao Zhang, Zhuolin Li, Xiao-Yu Liu, Chongyuan Wang, Hongda Huang, Ning Jia
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-12-01 |
Deskripsi
The authors report several high-resolution functional snapshots of type III-E nuclease-protease Craspase complexes, revealing the mechanisms underlying target RNA cleavage and non-self RNA activated protease activities; and highlighting the potentials for the development of RNA-guided nuclease-protease Craspase-based tools for biotechnological applications.