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The present paper aims to investigate the impacts of entropy generation and thermal radiation on peristaltic blood flow of a Magneto-micropolar fluid in a tapered channel. The analysis is carried out by using the low Reynolds number and long wavelength approximations. The governing equations are solved by Adomian Decomposition Method (ADM) and the expressions for velocity, stream function, axial induced magnetic field, current density, microrotation component, pressure gradient and entropy generation are obtained. The effect of various physical parameters such as heat source/sink parameter, thermal radiation parameter, Prandtl number, Hartmann number, micropolar coupling parameter, phase difference, Brinkmann number and Bejan number is illustrated graphically. Results reveal that entropy generation deceases with an increase of magnetic parameter, whereas it decreases with an increase of thermal radiation parameter. Such result helps in biomedical sciences. Further, it is found that the micropolar fluid model is more suitable for biofluids like blood. Keywords: Peristaltic flow, Micropolar fluid, Entropy generation, Thermal radiation, Tapered asymmetric channel