Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues
oleh: Wasim N. Abdullah, Khaled Q. Shawakfeh, Naim H. Al-Said
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2005-12-01 |
Deskripsi
Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2- carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode.