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Herein, we report a rare case of metastatic secondary cardiac myxofibrosarcoma in a 33-year-old female patient. The tumor infiltrated the right lung and was extending into the heart via the right superior pulmonary vein. The patient who initially presented with a stroke was found to be at a high risk of recurrent embolic events and therefore was managed successfully surgically with a complex joint thoracic and cardiac tumor resection. This case illustrates that, in the setting of an extensive metastatic myxofibrosarcoma, an aggressive palliative surgical resection can be successfully performed to improve quality of life.