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Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
oleh: Hüseyin Eken, Orhan Cimen, Ferda Keskin Cimen, Eray Kurnaz, Murat Yildirim, Volkan Tasova, Nezahat Kurt, Kamil Pehlivanoglu, Didem Onk, Asli Ozbek Bilgin
Format: | Article |
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Diterbitkan: | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2019-05-01 |
Deskripsi
Abstract Purpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.