Assessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival
oleh: Carlos Loucera, Javier Perez-Florido, Carlos S. Casimiro-Soriguer, Francisco M. Ortuño, Rosario Carmona, Gerrit Bostelmann, L. Javier Martínez-González, Dolores Muñoyerro-Muñiz, Román Villegas, Jesus Rodriguez-Baño, Manuel Romero-Gomez, Nicola Lorusso, Javier Garcia-León, Jose M. Navarro-Marí, Pedro Camacho-Martinez, Laura Merino-Diaz, Adolfo de Salazar, Laura Viñuela, The Andalusian COVID-19 Sequencing Initiative, Jose A. Lepe, Federico Garcia, Joaquin Dopazo
| Format: | Article |
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| Diterbitkan: | MDPI AG 2022-08-01 |
Deskripsi
Objectives: More than two years into the COVID-19 pandemic, SARS-CoV-2 still remains a global public health problem. Successive waves of infection have produced new SARS-CoV-2 variants with new mutations for which the impact on COVID-19 severity and patient survival is uncertain. Methods: A total of 764 SARS-CoV-2 genomes, sequenced from COVID-19 patients, hospitalized from 19th February 2020 to 30 April 2021, along with their clinical data, were used for survival analysis. Results: A significant association of B.1.1.7, the alpha lineage, with patient mortality (log hazard ratio (LHR) = 0.51, C.I. = [0.14,0.88]) was found upon adjustment by all the covariates known to affect COVID-19 prognosis. Moreover, survival analysis of mutations in the SARS-CoV-2 genome revealed 27 of them were significantly associated with higher mortality of patients. Most of these mutations were located in the genes coding for the S, ORF8, and N proteins. Conclusions: This study illustrates how a combination of genomic and clinical data can provide solid evidence for the impact of viral lineage on patient survival.