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This study navigates the intricate landscape of the Mureș River's upper course, specifically through the contrasting terrains of the Giurgeu Depression and the Toplița-Deda Gorge. It examines the unique relief features and substrates that define the vertical dynamics of the riverbed. The investigation focuses on data collected from four pivotal hydrometric stations: Suseni, Toplița, Stânceni, and Gălăoaia. Here, we determine the thickness of the rock layer (hp) by calculating the difference between the water level and the maximum depth, in relation to the gauge's zero plane. Our analysis highlights the riverbed's monthly regradation patterns within these locales. We uncover notable variations in the scope of vertical dynamics, delineate characteristic periods, and decipher both linear and polynomial trends.