PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans
oleh: Jieyu Wu, Xue Jiang, Yamei Li, Tingting Zhu, Jingjing Zhang, Zhiguo Zhang, Linqiang Zhang, Yuru Zhang, Yanli Wang, Xiaoju Zou, Bin Liang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-03-01 |
Deskripsi
Nucleolar stress can disrupt ribosome biogenesis and in turn energy metabolism and lipid storage, but how this is regulated is unclear. Here, the authors show in C. elegans that the transcription factor PHA-4/FOXA acts as a sensor for nucleolar stress and can regulate expression of lipogenic genes