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Glycan-dependent cell adhesion mechanism of Tc toxins
oleh: Daniel Roderer, Felix Bröcker, Oleg Sitsel, Paulina Kaplonek, Franziska Leidreiter, Peter H. Seeberger, Stefan Raunser
Format: | Article |
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Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
Although Tc toxins are a major class of bacterial toxin translocation systems, little is known about their receptor binding. Here, the authors identify heparins/heparan sulfates and Lewis antigens as receptors for different Tc toxins, determine cryo-EM structures of three toxin-glycan complexes and propose a two-step cell adhesion mechanism for Tc toxins.