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The pathogenesis of acne vulgaris (AV) is multifactorial and inflammation, which is primarily cause by induction of immunological response to Propionibacterium acnes (P. acnes), is suggested as the main important factor in AV development. These bacteria can be found in the form of papules and pustules in inflammatory lesions and as comedones in noninflammatory lesions, with a higher presentation seen in the inflammatory lesions. Clinically, comedo is a noninflammatory lesion; however, inflammation can be observed microscopically. P. acnes can release proinflammatory cytokines, including IL-17. The aim of this study was to compare the IL-17 serum level between papulopustular type and comedonal type of AV. This study was a cross sectional-analytic observational, conducted at the Cosmetic Dermatology Clinic, Dermatology and Venereology, Dr. Hasan Sadikin General Hospital Bandung during October–November 2014. The participants were AV patients with at least second degree papulopustular (n12) and comedonal types (n12). Blood samples from all subjects were collected and the IL-17 serum levels were measured using ELISA methods. This study showed that the mean (single deviation) IL-17 serum levels in papulopustular and comedonal type of AV were 0.65 (1.12) pg/mL and 0.46 (0.42) pg/mL, respectively, and the difference was not statistically significant (p:1.000). The IL-17 serum level in the papulopustular type is not different from that of the comedonal type of AV in this study, which indicates that the inflammatory events probably had occurred in comedonal lesions.