The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis
oleh: Pietro Di Fazio, Regine Schneider-Stock, Daniel Neureiter, Kinya Okamoto, Till Wissniowski, Susanne Gahr, Karl Quint, Matthias Meissnitzer, Beate Alinger, Roberta Montalbano, Gabriele Sass, Bernd Hohenstein, Eckhart G. Hahn, Matthias Ocker
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2010-01-01 |
Deskripsi
Inhibition of deacetylases represents a new treatment option for human cancer diseases. We applied the novel and potent pan-deacetylase inhibitor panobinostat (LBH589) to human hepatocellular carcinoma models and investigated by which pathways tumor cell survival is influenced.