Characterization of low level viraemia in HIV-infected patients receiving boosted protease inhibitor-based antiretroviral regimens
oleh: Francesca Ferretti, Nicola E. Mackie, Gurmit Kaur Jagjit Singh, Julie Fox, Steve Kaye, Myra O. McClure, Graham Taylor, Marta Boffito
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2019-09-01 |
Deskripsi
To understand the pathogenesis of low level viraemia (LLV) in HIV-infected patients on boosted protease inhibitors (PI/b), we enrolled 34 subjects with a median HIV-RNA 79 copies/mL and followed them for 15 months. Samples for next generation sequencing were collected at three time-points. Two showed resistance-associated mutations (RAMs) in the protease gene, while 95–100% had RAMs in the gag gene, which evolved in approximately a quarter of subjects, suggesting a potential clinical role of these kind of mutations.