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Zoonotic transmission of <i>orthohantaviruses</i> from rodent reservoirs to humans has been the cause of severe fatalities. Human infections are reported worldwide, but vaccines have been approved only in China and Korea. <i>Orthohantavirus</i> vaccine development has been pursued with no sense of urgency due to the relative paucity of cases in countries outside China and Korea. However, the <i>orthohantaviruses</i> continuously evolve in hosts and thus the current vaccine may not work as well against some variants. Therefore, a more effective vaccine should be prepared against the <i>orthohantaviruses</i>. In this review, we discuss the issues caused by the <i>orthohantavirus</i> vaccine. Given the pros and cons of the <i>orthohantavirus</i> vaccine, we suggest strategies for the development of better vaccines in terms of pandemic preparedness.