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Intracranial abscess, including subdural empyema, is a rare central nervous system infectious disease and diagnosis is often delayed due to patient presentation with non-specific neurologic findings. Here we report a 65-year-old male with a recent past medical history of SARS-CoV-2 infection who presented with three weeks of escalating headache in whom MRI imaging revealed a subdural empyema. He subsequently underwent two craniectomies, which resulted in eradication of the abscess and clinical improvement. This report highlights a potential link between SARS-CoV-2 infection and this patient's development of subdural empyema, which has not been documented elsewhere in the literature.