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Abstract Background Nurses have always been at the forefront of providing services for victims of disasters. Using nurses’ experiences in disaster planning can play an important role in improving their readiness to provide healthcare during disasters. The objective of this study is not only to understand the challenges but also to explore and document the broader spectrum of experiences encountered by nurses in these critical situations. By focusing on their experiences, we aim to contribute valuable insights to enhance disaster preparedness and healthcare delivery strategies. Methods This qualitative study employed the content analysis method to describe the experiences of 16 earthquake relief nurses in Kermanshah, Iran. Sampling was done purposefully and continued until data saturation was achieved. Initially, two unstructured interviews were conducted to shape the interview’s main line and refine guide questions. Subsequently, the study involved semi-structured interviews and observation notes for a nuanced understanding of the participants’ experiences. Results In the analysis of the interviews, 920 codes were obtained and the nurses’ experiences were categorized into three main categories: personal experiences, operational experiences, and social and cultural experiences. These three categories covered 12 subcategories. Conclusion Results of describing nurses’ experiences in the Kermanshah earthquake showed that nurses need to plan and implement necessary measures to ensure pre-disaster preparedness to respond effectively to disasters such as earthquakes. Besides, it is necessary to prepare, train and practice these interventions regularly, periodically, and purposefully. They should be evaluated and updated if they are used in a real earthquake or practice and maneuver.