nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors
oleh: Hai-Ying Liang, Zhi-Jin Chen, Hui Xiao, Yu-Hui Lin, Ying-Yi Hu, Lei Chang, Hai-Yin Wu, Peng Wang, Wei Lu, Dong-Ya Zhu, Chun-Xia Luo
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-05-01 |
Deskripsi
Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.