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Introduction . Despite the progress that has been made in the therapy of atopic dermatitis in recent years, cyclosporin A remains the first-line treatment of severe forms of the disease. Objective. To present a case of effective cyclosporin A therapy of severe atopic dermatitis with features of secondary bacterial infection. Case report . A 22-year-old man was admitted to hospital with extensive erythematous-desquamative skin lesions. The lesions were accompanied by intense itching. Based on the patient’s medical history, physical examination, laboratory test results and histological examination of a skin biopsy, atopic dermatitis with bacterial superinfection was diagnosed. Treatment with cyclosporin A in combination with antibiotics was initiated, resulting in significant clinical improvement within a few days after the initiation of therapy. Conclusions . Our case confirms that cyclosporin A is a fast-acting and highly effective therapeutic agent in atopic dermatitis, and the risk of adverse reactions, if the drug is used properly, is low.