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Iatrogenic splenic injury (SI) is known to occur during various procedures. Any unusual course in postoperative period or hypotension should raise suspicion of SI, especially in the left nephrectomy or colonic resection. Sonography of abdomen by an expert should be the first investigation after a medical cause is ruled out. Splenic salvage may be attempted. There should be a low threshold for splenectomy to save the life of the patient.