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<i>Background and objectives:</i> Chronic kidney disease (CKD)-associated pruritus is a common and disturbing condition which has a negative impact on sleep quality, as well as overall health-related quality of life of patients receiving hemodialysis. To date, no systematic review has been undertaken, and there is a lack of concise evidence that statistically quantifies the impact of pruritus based on published data. <i>Materials and Methods:</i> A systematic search was done for original articles published in peer-reviewed English journals from database inception on 20 December, 2018, in the following databases: PubMed, MEDLINE, EMBASE, Ovid, CINHAL, ProQuest, and Scopus. <i>Results:</i> A total of 9217 research articles were identified. After removal of duplicates and screening for titles and abstracts, 28 articles were selected. The prevalence of disturbed sleep was 4&#8722;94%, while the pooled proportion on random effect in the study was 40% (95% CI = 0.30 to 0.49); I² = 99.8%. However, the prevalence of disturbed sleep quality and quantity due to pruritus was 9&#8722;76%, and the pooled proportion on random effect in the study was 50% (95% CI = 0.37 to 0.64); I² = 99.8%. <i>Conclusions:</i> Patients undergoing hemodialysis who are affected by CKD-associated pruritus have a higher chance of experiencing sleep disturbances. The prevalence of disturbed sleep due to CKD-associated pruritus was found to be 9&#8722;76% in the included studies for patients receiving hemodialysis therapy.