Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
oleh: Melissa A. Meyer, John M. Baer, Brett L. Knolhoff, Timothy M. Nywening, Roheena Z. Panni, Xinming Su, Katherine N. Weilbaecher, William G. Hawkins, Cynthia Ma, Ryan C. Fields, David C. Linehan, Grant A. Challen, Roberta Faccio, Rebecca L. Aft, David G. DeNardo
Format: | Article |
---|---|
Diterbitkan: | Nature Portfolio 2018-03-01 |
Deskripsi
Tumors escape the immune system through many mechanisms. Here the authors show that certain tumors inhibit anti-tumor immunity by stopping the production of conventional dendritic cells (cDCs) in the bone marrow, therefore depleting the pool of cDCs available to present antigen to CD8+ T cells.