Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
oleh: Minzhe Guo, Yina Du, Jason J. Gokey, Samriddha Ray, Sheila M. Bell, Mike Adam, Parvathi Sudha, Anne Karina Perl, Hitesh Deshmukh, S. Steven Potter, Jeffrey A. Whitsett, Yan Xu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
The respiratory system is transformed in terms of functional change at birth to adapt to breathing air. Here, the authors examine the molecular changes behind the first breath in the mouse by Drop-seq based RNA sequencing, identifying activation of the unfolded protein response as a perinatal adaptation of the lung.