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Alzheimer's disease (AD) is a neurodegenerative brain disorder that affects memory, thinking, concentration, and judgment, ultimately hindering a person's ability to perform routine daily activities. However, drug delivery to the brain is quite tricky because of the presence of the Blood-Brain barrier and various limitations of oral and other routes, like reduced bioavailability, fast metabolism, rapid elimination, and drug degradation by enzymes and gastric juices. To overcome the limitations of oral and other routes of administration, novel drug delivery systems are being developed for brain targeting, and the nose-to-brain drug delivery system is one of the novel approaches for targeting the brain.Our methodology involved a preliminary search on the PubMed, OVID Medline, Embase, ScienceDirect, Web of Science, and Google Scholar databases where keywords such as “Alzheimer's disease, Intranasal delivery, nose-to-brain drug delivery, formulations for intranasal delivery” were used.This review outlined intranasal drug delivery, i.e., nose-to-brain drug delivery, is one of the effective, safe, and non-invasive methods to target the brain as it bypasses the Blood-Brain barrier. Therefore, many novel techniques, like nanoparticles, in-situ gels, nano-emulsions, hydrogels, liposomes, and others, are widely used for the treatment of Alzheimer's disease effectively by avoiding the Blood-Brain barrier.