WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour
oleh: Shiu-Ling Chen, Bo-Ting Liu, Wang-Pao Lee, Sin-Bo Liao, Yao-Bang Deng, Chia-Lin Wu, Shuk-Man Ho, Bing-Xian Shen, Guan-Hock Khoo, Wei-Chiang Shiu, Chih-Hsuan Chang, Hui-Wen Shih, Jung-Kun Wen, Tsuo-Hung Lan, Chih-Chien Lin, Yu-Chen Tsai, Huey-Fen Tzeng, Tsai-Feng Fu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
The authors show that the Drosophila master regulator WAKE modulates the secretion of insulin-like peptides, triggering a decrease in 20-hydroxyecdysone levels. This lowers the perception of a male-specific sex pheromone and explains why WAKE-deficient Drosophila flies show male-male courtship behaviour.