Impact of Bacille Calmette-Guérin revaccination on serum IgE levels in a randomized controlled trial
oleh: Thaís Silva Peleteiro, Evelin Santos Oliveira, Elisabete Lopes Conceição, Francisco Nascimento-Sampaio, Neuza Maria Alcântara-Neves, Carlos Mauricio Cardeal Mendes, Theolis Costa Barbosa Bessa
| Format: | Article |
|---|---|
| Diterbitkan: | Sociedade Brasileira de Medicina Tropical (SBMT) |
Deskripsi
Abstract INTRODUCTION: Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection. METHODS: Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial. RESULTS: Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels. CONCLUSIONS: BCG responsiveness does not affect protection against atopy.