Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice
oleh: Tzong-Shiue Yu, Yacine Tensaouti, Elizabeth P. Stephanz, Sana Chintamen, Elizabeth E. Rafikian, Mu Yang, Steven G. Kernie
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-11-01 |
Deskripsi
Tzong-Shiue Yu et al. assess the impact of astrocytic ApoE on hippocampal neurogenesis and behavior after traumatic brain injury (TBI) in mice. Their results suggest that postnatal ablation of astrocytic APOE reduces dendritic complexity in newborn dentate gyrus neurons and cognitive ability, providing further insight into a role for APOE in injury-induced neurogenesis following TBI.