Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis
oleh: Nan W. Hultgren, Jennifer S. Fang, Mary E. Ziegler, Ricardo N. Ramirez, Duc T. T. Phan, Michaela M. S. Hatch, Katrina M. Welch-Reardon, Antonio E. Paniagua, Lin S. Kim, Nathan N. Shon, David S. Williams, Ali Mortazavi, Christopher C. W. Hughes
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
Slug supports heart development and tumor metastasis, but its role in blood vessel formation is less clear. Here the authors show that endothelial cell-expressed Slug regulates both physiologic and pathological angiogenesis, at least in part through the modulation of Notch signalling.