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Among the seven species of <i>Entamoeba</i> known to infect humans, <i>E. histolytica</i> is widely recognized as a pathogen. It is reported that <i>Entamoeba</i> infections are common in the developing world, but rare in developed countries. The best way to diagnose these protozoan parasites is to detect antigens or DNA in the stool. This study aimed to review the prevalence, distribution, and diagnosis methods of <i>Entamoeba</i> spp. infecting humans in the Americas between 1990 and 2022. A systematic review and meta-analysis were performed, including 227 studies on <i>Entamoeba</i> infections from 30 out of 35 American countries. The pooled prevalence of each species of <i>Entamoeba</i> was calculated using the random-effects model. The assignment of <i>Entamoeba</i> species was mainly performed by microscopy. The most widely distributed and prevalent species was <i>E. coli</i> (21.0%). Of the studies, 49% could not differentiate the species of the <i>Entamoeba</i> complex. The pathogenic species <i>E. histolytica</i> was distributed among 22 out of 30 American countries studied, with a pooled prevalence of 9%. Molecular data on <i>Entamoeba</i> species are still scarce. This is the first study that reviewed and summarized data on the prevalence of this protozoan genera among American countries.