Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate
oleh: Stephen A. McMahon, Wenlong Zhu, Shirley Graham, Robert Rambo, Malcolm F. White, Tracey M. Gloster
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Antiviral defence type III CRISPR systems produce cyclic oligoadenylates (cOA) as second messengers that activate downstream effectors. Here the authors present the crystal structure of the type III CRISPR defence DNA nuclease Can1 in complex with cyclic tetra-adenylate (cA4) and show that Can1 nicks supercoiled DNA.