Rational Design and Synthesis of Large Stokes Shift 2,6-Sulphur-Disubstituted BODIPYs for Cell Imaging
oleh: Abigail E. Reese, Charles Lochenie, Ailsa Geddis, Luana A. Machado, Marcos C. de Souza, Flávia F. C. Marques, Carlos A. de Simone, Marcos M. Gouvêa, Leandro F. Pedrosa, Eufrânio N. da Silva Júnior, Marc Vendrell
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2022-01-01 |
Deskripsi
Five new disubstituted 2,6-thioaryl-BODIPY dyes were synthesized via selective aromatic electrophilic substitution from commercially available thiophenols. The analysis of the photophysical properties via absorption and emission spectroscopy showed unusually large Stokes shifts for BODIPY fluorophores (70–100 nm), which makes them suitable probes for bioimaging. Selected compounds were evaluated for labelling primary immune cells as well as different cancer cell lines using confocal fluorescence microscopy.