Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma
oleh: Katrin Rabold, Martijn Zoodsma, Inge Grondman, Yunus Kuijpers, Manita Bremmers, Martin Jaeger, Bowen Zhang, Willemijn Hobo, Han J. Bonenkamp, Johannes H. W. de Wilt, Marcel J. R. Janssen, Lenneke A. M. Cornelissen, Ilse C. H. van Engen-van Grunsven, Willem J. M. Mulder, Jan W. A. Smit, Gosse J. Adema, Mihai G. Netea, Yang Li, Cheng-Jian Xu, Romana T. Netea-Maier
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
Myeloid cells contribute to the tumor microenvironment of thyroid cancers, but their functional relevance is lesser known. Here authors show that myeloid cells infiltrating non-medullary thyroid carcinomas upregulate their antigen presentation-related genes, release less cytokines and over-produce reactive oxygen species, with transcriptional changes already present in extra-tumoral myeloid cells.