Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy
oleh: Olesia Ignatenko, Dmitri Chilov, Ilse Paetau, Elena de Miguel, Christopher B. Jackson, Gabrielle Capin, Anders Paetau, Mugen Terzioglu, Liliya Euro, Anu Suomalainen
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-01-01 |
Deskripsi
Astrocytes in the brain are metabolically dynamic. Here, Ignatenko, Chilov and colleagues delete mitochondrial DNA (mtDNA) in a cell type specific manner, and show that inactivation of mtDNA helicase Twinkle in astrocytes leads to spongiotic encephalopathy.