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Secondary angle-closure glaucoma (ACG) due to pupillary block in pseudophakic patients has numerous reports in the literature. We report a 60-year-old pseudophakic patient with occurrence of unilateral non-pupillary block secondary ACG caused by vitreous prolapse after laser capsulotomy. He received topical and oral aqueous suppressants as treatment, and he underwent anterior vitrectomy with pars plana vitrectomy. This report aims to supplement the scant literature on this condition and to educate clinicians of the value of imaging in secondary ACG with non-pupillary block in pseudophakic patients to determine the cause and tailor treatment.