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This article summarizes our current knowledge about HLB-associated preharvest fruit drop. Unfortunately, exactly how HLB induces preharvest fruit drop is still unknown. Nonetheless, this article links what we do know about HLB-associated fruit drop to fruit drop in HLB-free trees; and how strategies such as managing tree water status and use of gibberellic acid can be useful in reducing HLB-associated preharvest fruit drop.