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This paper highlights findings on cancer trends from the Canadian Cancer Statistics 2021 report. Trends were measured using annual percent change (APC) of age-standardized incidence rates. Overall, cancer incidence rates are declining (−1.1%) but the findings are specific to the type of cancer and patient sex. For example, in males, the largest decreases per year were for prostate (−4.4%), colorectal (−4.3%), lung (−3.8%), leukemia (−2.6%) and thyroid (−2.4%) cancers. In females, the largest decreases were for thyroid (−5.4%), colorectal (−3.4%) and ovarian (−3.1%) cancers.