Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause
oleh: Rui Fan, Yung Su Kim, Jie Wu, Rui Chen, Dagmar Zeuschner, Karina Mildner, Kenjiro Adachi, Guangming Wu, Styliani Galatidou, Jianhua Li, Hans R. Schöler, Sebastian A. Leidel, Ivan Bedzhov
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
Embryonic diapause is a state of dormancy with poorly understood mechanisms of embryo intrinsic regulation. Here, the authors show that murine diapause is a dynamic process, where tissue-scale reorganization of the pluripotent lineage is controlled in an autocrine manner by the Wnt/b-catenin/Esrrb signalling cascade.