Luciferase-induced photoreductive uncaging of small-molecule effectors
oleh: Eric Lindberg, Simona Angerani, Marcello Anzola, Nicolas Winssinger
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
Bioluminescence resonance energy transfer (BRET) has been mostly employed in imaging applications. Here the authors use BRET to activate a ruthenium-based photocatalyst and perform a bioorthogonal chemical reaction, which can be used to uncage small molecule drugs in a cellular context.