The RNA-binding protein HuR is required for maintenance of the germinal centre response
oleh: Ines C. Osma-Garcia, Dunja Capitan-Sobrino, Mailys Mouysset, Sarah E. Bell, Manuel Lebeurrier, Martin Turner, Manuel D. Diaz-Muñoz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-11-01 |
Deskripsi
Germinal centre (GC) responses may require RNA binding proteins (RBP) for post-transcriptional gene regulation. Here the authors show the RBP HuR supports GCs by promoting Myc and Myc-dependent transcription to enhance antigen-specific GC B cell selection and production of high affinity antibodies.