The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth
oleh: Jeongkyu Kim, Philipp Oberdoerffer, Simran Khurana
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-05-01 |
Deskripsi
The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-modulated macroH2A1 chromatin organization for cell function and malignant transformation.