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One-pot four-component reaction for convenient synthesis of functionalized 1-benzamidospiro[indoline-3,4'-pyridines]
oleh: Chao Wang, Yan-Hong Jiang, Chao-Guo Yan
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2014-11-01 |
Deskripsi
The one-pot four-component reaction of benzohydrazide (2-picolinohydrazide), acetylenedicarboxylate, isatins and malononitrile (ethyl cyanoacetate) with triethylamine as base catalyst afforded functionalized 1-benzamidospiro[indoline-3,4'-pyridines] in good yields. 1H NMR spectra indicated that an equilibrium of cis/trans-conformations exist in the obtained products.