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In this letter, we study the charge response from higher derivatives over the background with homogeneous disorder introduced by axions. We first explore the bounds on the higher derivatives coupling from DC conductivity and the anomalies of causality and instabilities. Our results indicate no tighter constraints on the coupling than that over Schwarzschild–AdS (SS–AdS) background. And then we study the optical conductivity of our holographic system. We find that for the case with γ1<0 and the disorder strength αˆ<2/3, there is a crossover from a coherent to incoherent metallic phase as αˆ increases. When αˆ is beyond αˆ=2/3 and further amplified, a peak exhibits again at low frequency. But it cannot be well fitted by the standard Drude formula and new formula for describing this behavior shall be called for. While for the holographic system with the limit of γ1→1/48, the disorder effect drives the hard-gap-like at low frequency into the soft gap and suppresses the pronounced peak at medium frequency.