Reductive Deuteration of Acyl Chlorides for the Synthesis of <i>α</i>,<i>α</i>-Dideuterio Alcohols Using SmI<sub>2</sub> and D<sub>2</sub>O
oleh: Hengzhao Li, Yuxia Hou, Mengqi Peng, Lijun Wang, Junyu Li, Lei Ning, Zemin Lai, Yixuan Li, Jie An
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2023-01-01 |
Deskripsi
The synthesis of <i>α</i>,<i>α</i>-dideuterio alcohols has been achieved via single electron transfer reductive deuteration of acyl chlorides using SmI<sub>2</sub> and D<sub>2</sub>O. This method is distinguished by its remarkable functional group tolerance and exquisite deuterium incorporation, which has also been applied to the synthesis of valuable deuterated agrochemicals and their building blocks.