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Objective: To evaluate the role of oral ondansetron as an effective measure to facilitate oral rehydration in acute gastroenteritis. Study Design: Randomized controlled trail. Place and Duration of Study: Army medical college, Military hospital Rawalpindi, from Mar 2017 to Sep 2017. Material and Methods: One hundred and forty children with clinical diagnosis of acute gastroenteritis with mild to moderate dehydration were randomized into two equal groups. Group 1 was treated according to the WHO criteria with only ORS in a dose of 75ml/kg body weight. Group 2 received ondansetron before ORS as a single oral dose of 0.2mg/kg body weight. Results: The difference between improvement in drinking ability and hydration status between the two groups was highly significant (p<0.001). Conclusion: Ondansetron markedly improved the hydration status and drinking ability of the children by reducing nausea and vomiting.