Trichloroethylene increases pulmonary endothelial permeability: implication for pulmonary veno-occlusive disease
oleh: Julien Caliez, Marianne Riou, Grégoire Manaud, Morad K. Nakhleh, Marceau Quatredeniers, Catherine Rucker-Martin, Peter Dorfmüller, Florence Lecerf, Maria C. Vinhas, Salam Khatib, Hossam Haick, Sylvia Cohen-Kaminsky, Marc Humbert, David Montani, Frédéric Perros
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2020-10-01 |
Deskripsi
Trichloroethylene exposure is a major risk factor for pulmonary veno-occlusive disease. We demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, through vascular endothelial (VE)-Cadherin internalisation, and suggested that this mechanism may play a role in the development of pulmonary veno-occlusive disease.