Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
oleh: Charles D. Cox, Chilman Bae, Lynn Ziegler, Silas Hartley, Vesna Nikolova-Krstevski, Paul R. Rohde, Chai-Ann Ng, Frederick Sachs, Philip A. Gottlieb, Boris Martinac
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-01-01 |
Deskripsi
PIEZO1 is a mechanosensitive ion channel, but the mechanism of force transduction is unknown. Here Cox and Bae et al.disrupt the cortical cytoskeleton in HEK293 cells to show that PIEZO1 is gated directly by membrane tension.