A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR
oleh: Anne Grahl, Layara Akemi Abiko, Shin Isogai, Timothy Sharpe, Stephan Grzesiek
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-05-01 |
Deskripsi
Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by ligands occurs via modulation of complex conformational equilibria. Here authors quantify these equilibria and their dynamics in the β1-adrenergic receptor in its apo form and seven ligand complexes using NMR.