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Introduction. Co-morbid diseases are commonly associated with chronic obstructive pulmonary disease such as depression, anxiety, etc. The objective of study was to determine the prevalence of depression and its factors associated with chronic obstructive pulmonary disease among hospital patients. Methods. It’s a cross sectional study and total 54 patients were selected through simple random sampling from chest ward of tertiary care hospital. Validated patient health questionnaire (PHQ-9) questionnaire was used to determine the depression among COPD patients. Binary logistic regression model was used to determine the association between depression with COPD with adjustment of duration of disease, gender and age. Cronbach alpha was calculated to assess internal consistency of PHQ-9. Results. Approximately 35.2%, 27.8% and 37% of COPD patients were suffered moderate, moderate severe and severe depression respectively. After adjustment of covariates in logistic regression analysis the common factors were females [OR 1.20 (CI 1.11-4.56)], smoker [OR 1.55 (CI 1.13-2.22)], and more than 10-year of duration of COPD [OR 1.01(CI 1.00-1.14)] statistically significant predictors of depression in COPD patients. Conclusions. COPD patients had high prevalence of depression. Females gender, smoking and duration of disease were common factors associated with depression among these patients. There is need for developing health promotion programs such as counseling of patients with psychiatrist to reduce the burden of depression among COPD patients.