Structure of a nucleosome-bound MuvB transcription factor complex reveals DNA remodelling
oleh: Marios G. Koliopoulos, Reyhan Muhammad, Theodoros I. Roumeliotis, Fabienne Beuron, Jyoti S. Choudhary, Claudio Alfieri
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
The MuvB family of protein complexes regulate cell cycle-dependent transcription, and MuvB in complex with the transcription factors B-MYB and FOXM1 activate mitotic genes during G2. Here the authors present cryo-EM data of a MuvB:B-MYB (MMB) complex in the process of remodelling a nucleosome, and define its stoichiometry, assembly, and chromatin binding.