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Objective To observe the clinical effect of COVID-19 treated with fibronectin inhalation. Methods Forty-eight COVID-19 patients in Department of Neurology, Xiehe Hospital,Tongji Medical College,Wuhan Huazhong University of Science and Technology,were treated with aerosol inhalation of fibronectin skin antibacterial liquid,respectively. Aerosol inhalation of fibronectin for 7-14 days was given twice a day,about 15 mL of aerosol solution each time. The duration of aerosol administration was 10-15 minutes. Results After inhalation of fibronectin for 7-14 days,the patients were given atomization twice a day,and each time the atomization liquid was about 15 mL,the clinical manifestations of patients showed that dyspnea improved,cough reduction,sputum reduction,pulmonary exudate reduction,sputum smooth and CT imaging lesions decreased. Conclusions Inhalation of fibronectin is effective for the treatment of COVID-19 infection.