Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells
oleh: Lara Ribeiro-Parenti, Anne-Charlotte Jarry, Jean-Baptiste Cavin, Alexandra Willemetz, Johanne Le Beyec, Aurélie Sannier, Samira Benadda, Anne-Laure Pelletier, Muriel Hourseau, Thibaut Léger, Bastien Morlet, Anne Couvelard, Younes Anini, Simon Msika, Jean-Pierre Marmuse, Sévérine Ledoux, Maude Le Gall, André Bado
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
GLP-1 is a gastrointestinal peptide that regulates gastric acid secretion and emptying, and due to the rapid degradation of intestinally secreted GLP-1 local gastric production has been suggested. Here the authors report the presence of GLP-1 expressing cells in the rat and human stomach, which contribute to the circulating GLP-1 levels and are affected by weight loss surgeries.